精神状态解码和精神状态推理在精神分裂症中的神经相关性
Cemal Demirlek1, Merve Karakılıç2, Ecenaz Sarıkaya2
1Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Psychiatry research. Neuroimaging
|November 18, 2023
概括
这项研究揭示了与精神分裂症精神缺陷理论相关的独特大脑结构. 神经成像发现了与精神状态解码和推理能力相关的特定皮质和白质差异.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 认知神经科学 认知神经科学
背景情况:
- 在精神分裂症中,思维理论 (ToM) 技能受到损害,影响社会认知.
- 不同的ToM任务评估不同的神经认知功能,需要有针对性的调查.
研究的目的:
- 研究精神状态解码和精神分裂症中的推理的神经解剖学的基础.
- 通过多式神经成像,将社会认知表现与结构性大脑参数联系起来.
主要方法:
- 使用多模式神经成像 (T1加权的MRI和扩散张力成像 (DTI)).
- 招募了62名精神分裂症患者和34名健康对照 (HC).
- 阅读眼睛中的思维 (RMET) 和暗示测试评估了ToM组件.
主要成果:
- 精神分裂症患者在RMET得分和左侧胰岛的厚度,右侧上关节的厚度和左侧上关节的结体积之间显示出相关性.
- DTI揭示了RMET得分与右下前后囊和左大囊中的分数异质性之间的关联.
- 在精神分裂症中,暗示测试得分与左上神经体体积/表面积和左侧神经体积相关.
结论:
- 特定的皮质区域和白质道与精神分裂症中观察到的精神状态解码和推理的破坏有关.
- 这种多模式的方法突出了不同ToM组件的独特神经解剖相关性.
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