植物性乳杆菌调节肠道微生物群和循环胺治疗小鼠模型中的肠道免疫力
Zhibo Zeng1, Zonghao Huang2, Wen Yue2
1Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences/Fujian Key Laboratory of Animal Genetics and Breeding, Fuzhou 350013, China; Institute of Agricultural Sciences, ETH Zurich, Universitaetstrasse 2, 8092 Zurich, Switzerland.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|November 18, 2023
概括
在免疫抑制小鼠中,Lactobacillus plantarum的管理增强了免疫功能. 这种益生菌恢复了免疫标记物,增加了杯细胞,并使炎症性细胞因子表达正常化,突出了其调节肠道微生物群和免疫力的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群 (GM) 在免疫调节中起着至关重要的作用.
- 植物乳杆菌,转基因和免疫功能之间的特定相互作用需要进一步阐明.
研究的目的:
- 为了研究Lactobacillus plantarum在循环胺诱导的免疫抑制小鼠模型中的免疫增强作用.
- 分析Lactobacillus plantarum对肠道微生物群组成和免疫反应的影响.
主要方法:
- 循环胺治疗以诱导免疫抑制.
- 血素-氨酸染色,免疫组织化学,16S rRNA基因测序和RT-PCR进行分析.
- 施用 Lactobacillus plantarum 来评估其影响.
主要成果:
- 在免疫抑制小鼠 (P <0.05) 中,植物乳杆菌恢复了中的免疫标记体表达,并增加了肠道杯细胞.
- 肠道微生物群的组成发生了转变,Firmicutes减少,Verrucomicrobia和Actinobacteria增加.
- 植物性乳杆菌的施用恢复了炎症性细胞因子的抑制的mRNA表达.
结论:
- 植物乳杆菌在免疫抑制状态下表现出显著的免疫增强作用.
- 益生菌干预乳酸菌植物菌可以调节肠道微生物群并恢复免疫功能.
- 这些发现提供了关于益生菌,肠道微生物群和宿主免疫之间的相互作用的见解.
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