在Wnt-frizzled复杂结构动态中,Wnt棕烯酸环保护二硫化物键的作用:从分子动态模拟中的洞察力

N Dehghanbanadaki1, H Mehralitabar2, R Sotoudeh1

  • 1Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, PO Box: 14115-154, Tehran, Iran.

PubMed
概括

与色受体的Wnt蛋白相互作用由棕烯基基和关键的二硫化键稳定. 硫化物183-190是Wnt-FZ复合物的形成和稳定性的关键,提供了潜在的药物标.

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