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在家族地中海热病中的癌症发病率:回顾性分析

Sura Nur Baspinar¹, Berkay Kilic², Feyza Nur Azman²

¹Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.

Seminars in arthritis and rheumatism

|November 18, 2023

概括

与一般人群相比,土耳其家族地中海热 (FMF) 患者的癌症风险降低了36%. 这可能与长期使用抗炎药物,如菌素,在FMF管理相关.

科学领域:

类风湿病学类风湿病学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

家庭地中海热 (FMF) 是一种遗传性自身炎症性疾病.
FMF呈现出反复发烧和多菌炎.
科尔奇辛是FMF的主要治疗方法.

研究的目的:

为了研究诊断为FMF的土耳其患者的癌症风险.
为了将FMF患者的癌症发病率与土耳其普通人口进行比较.

主要方法:

对1734名土耳其FMF患者癌症结局的回顾性分析.
与国家癌症统计数据 (2018年) 相比,标准化发病率 (SIR) 的计算.
基于性别和生物剂使用的子组分析.

主要成果:

在68,784个人年内,在2%的FMF患者中观察到癌症.
FMF患者的癌症发病率显著降低 (SIR 0.64,p<0.01).
没有发现与生物制剂疗法有显著的癌症关联.

结论:

土耳其FMF患者患癌症的风险降低了36%.
长期的抗炎疗法,特别是素,可以解释这种保护作用.
需要进一步的研究来证实和阐明这种关联.

关键词:

癌症癌症癌症癌症科尔奇辛 (Colchicine) 是一种可口药.家庭地中海热病家族性地中海热恶性瘤是一种恶性瘤.这是一种抗IL-1的药物.

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