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将基于CuCo的纳米酶设计推向新的高度,通过三重类似酶的功率来实现高效的细菌根除

Zheng Liu¹, Ruibang Wu¹, Yulin Jiang¹

¹Analytical & Testing Center, West China Hospital & Department of Orthopedics Surgery and Orthopedic Research Institute, Chengdu 610065, China.

Colloids and surfaces. B, Biointerfaces

|November 18, 2023

概括

基于铜/的金属硫化物纳米颗粒 (CCS NPs) 通过产生活性氧物种 (ROS) 和耗尽谷氨 (GSH) 来表现出强大的抗菌活性. 这些纳米酶为治疗细菌感染和伤口提供了一个有希望的非抗生素方法.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

细菌感染对全球健康构成重大威胁,需要新型抗菌剂.
目前的抗生素治疗面临的挑战包括耐药性和副作用.
纳米酶提供了一个有前途的替代品,因为它们的调节性质和催化作用.

研究的目的:

合成和表征基于铜/的金属硫化物纳米粒子 (CCS NPs) 作为新型抗菌纳米酶.
调查CCSNP的抗菌机制,包括活性氧物种 (ROS) 生成和谷氨 (GSH) 枯竭.
为了评估CCSNP在治疗细菌感染的伤口中的疗效,在体外和体内.

主要方法:

基于铜/的金属硫化物纳米粒子 (CCS NPs) 的简单的热水合成.
对CCSNP的过氧化酶类,氧化酶类和GSH耗尽活动的测定.
通过使用ROS生成和细菌活力测试进行体外抗菌疗效测试.
在体内研究CCSNP治疗细菌感染的伤口,评估细菌消除和生物相容性.

主要成果:

中枢碳化合物NPs表现出内在的过氧化酶类和氧化酶类活动,有效地产生ROS.
中枢细胞核糖系NP有效地减少了细菌中的谷氨 (GSH),增加了氧化应激.
低度的H2O2与CCSNP显示出显著的体外抗菌作用.
在体内研究表明有效的细菌消除和良好的生物相容性在伤口治疗.

结论:

CCS NPs作为具有三重酶类活性 (氧化酶,氧化酶,GSH耗尽) 的多功能纳米酶起作用.
这些纳米酶为抗击细菌感染提供了强大的非抗生素策略.
CCS NPs在治疗细菌感染的伤口方面具有显著的潜力,具有良好的生物相容性.

关键词:

细菌根除细菌的消灭催化活动是催化活动.纳米酶纳米酶是一种纳米酶.有反应性氧物种的反应性氧物种.伤口愈合伤口愈合

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