阿托莫克西丁和特拉佐组合对阻塞性睡眠呼吸暂停和睡眠微观结构的影响:一项双盲随机临床试验研究
Mojtaba Shahbazi1, Reihaneh Heidari2, Abbas Tafakhori1
1Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sleep medicine
|November 18, 2023
概括
与安慰剂相比,阿托莫克赛丁和特拉佐 (A-T) 组合显著改善了阻塞性睡眠呼吸暂停 (OSA) 患者的呼吸事件指数. 这种AT组合可能为OSA患者提供替代治疗,这些患者对标准疗法没有反应.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,OSA) 是一种常见的睡眠障碍,其特点是睡眠期间重复出现上呼吸道崩.
- 目前用于OSA的治疗方法可能不是所有患者都能有效或耐受.
- 目前正在探索药理干预作为OSA管理的辅助或替代方案.
研究的目的:
- 评估阿托莫克西和特拉佐 (A-T) 组合在改善阻塞性睡眠呼吸暂停 (OSA) 患者呼吸事件指数方面的疗效.
- 为了比较AT组合与安慰剂在随机,双盲,交叉试验中的效果.
主要方法:
- 在成年OSA患者中进行了一项随机,安慰剂控制,双盲,交叉试验.
- 参与者接受了A-T组合 (atomoxetine 80 mg和trazodone 50 mg) 或安慰剂,分别服用两晚,间隔一周.
- 进行了多睡眠扫描,以评估睡眠参数和呼吸系统事件.
主要成果:
- 与安慰剂相比,AT组合显著降低了呼吸暂停-呼吸暂停指数 (AHI) (28.3比42.7,p=0.025).
- 在REM睡眠持续时间 (1.3%与13.1%,p=0.001),REM周期数量 (0.8与4.7,p=0.001) 和呼吸暂停数量 (38.3与79.3,p=0.011) 中观察到显著改善.
- 氧气脱度指数和呼吸刺激指数也随着AT组合而显著降低.
结论:
- 与安慰剂相比,atomoxetine和trazodone的组合在改善OSA患者的关键呼吸事件指数方面表现出显著的有效性.
- 这种AT组合值得在更大的临床试验中进一步研究.
- 它具有作为OSA患者的替代治疗选择的潜力,这些患者不遵守或受益于现有疗法.
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