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Updated: Jul 10, 2025

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通过tRNA-GCN2-FBXO22轴介导的mTOR无处不在感应氨基酸不足

Meng-Kai Ge1, Cheng Zhang2, Na Zhang3

  • 1Institute of Aging & Tissue Regeneration, State Key Laboratory of Systems Medicine for Cancer and Stress and Cancer Research Unit of Chinese Academy of Medical Sciences (No. 2019RU043), Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200127, China; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, SJTU-SM, Shanghai 200025, China.

Cell metabolism
|November 18, 2023
PubMed
概括

细胞氨基酸水平通过一种新的无处不在途径调节mTORC1的活动. 未充电的tRNA触发GCN2和FBXO22,使mTOR无处不在,在营养稀缺期间抑制其激酶功能.

关键词:
在FBXO2222中使用.在 GCN2 中.氨基酸是氨基酸中的一种.在mTOROR中使用mTOR.在 mTORC1 的情况下,mTORC1 是无处不在的化没有充电的tRNA.

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