胺的利用和缺乏规范的处方:一个批判性的检查
Todd N Brothers1, Margaret Furtado2, Mohammad A Al-Mamun3
1College of Pharmacy, The University of Rhode Island, Kingston, RI, United States; Roger Williams Medical Center, Providence, RI, United States.
Alcohol (Fayetteville, N.Y.)
|November 18, 2023
概括
患有酒精使用障碍 (AUD) 的住院患者和老年患者通常会接受更高的胺剂量. 具体的实验室发现可以帮助确定需要更多胺的患者,解决护理上的差距.
科学领域:
- 内部医学 内部医学
- 临床药理学 临床药理学
- 营养科学 营养科学
背景情况:
- 胺 (维生素B1) 缺乏是住院患者,特别是那些有酒精使用障碍 (AUD) 和老年人的担忧.
- 目前美国的临床指南缺乏在住院期间开 thiamine 的处方.
- 了解处方模式和患者特征对于优化护理至关重要.
研究的目的:
- 评估住院患者的胺处方模式.
- 为了确定与胺缺乏和更高剂量的关键患者特征.
- 解决当前临床护理中发现的差距.
主要方法:
- 从2021年9月到2022年3月的电子健康记录的回顾性分析.
- 使用临床研究所戒断评估分数或血清酒精含量来定义酒精使用障碍 (AUD).
- 定义老年患者年龄≥65.5岁.
- 利用多变量LASSO回归来确定与每天100毫克以上的胺剂量相关的因素.
主要成果:
- 酒精使用障碍 (AUD) 与较高的胺剂量 (OR 1.62; p < 0.01) 有意义地相关.
- 特定的实验室发现 (例如,白蛋白,INR,胆红素) 在AUD和非AUD队列之间有显著差异.
- 与年轻人队伍相比,老年患者也表现出不同的实验室配置文件.
结论:
- 在住院期间的胺处方模式是可变的.
- 特定的实验室发现可以帮助确定患有胺缺乏症风险较高的患者队列.
- 这项研究提供了潜在的洞察力,可以改善住院患者的胺管理.
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