多伦多青少年和青年队列研究:研究设计和与精神病谱症状,功能和自杀倾向相关的早期数据
Kristin Cleverley1, George Foussias1, Stephanie H Ameis1
1Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|November 18, 2023
概括
精神病谱症状 (PSSs) 在患有精神疾病的青少年中很常见,影响功能和增加自杀倾向. 早期TAY队列研究的结果强调需要更好地了解这些年轻人的发展轨迹.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 发展心理学 发展心理学
- 心理健康研究 心理健康研究
背景情况:
- 精神病谱症状 (PSS) 在年轻人中普遍存在,并与功能不良和自杀倾向等不良结果有关.
- 青少年中PSS的先例,特别是那些患有现有精神疾病的青少年,需要进一步调查.
- 多伦多青少年和青少年 (TAY) 队列研究是为了探索精神病患者青少年的发展途径而启动的.
研究的目的:
- 描述患有精神疾病的年轻人的发展轨迹.
- 了解PSS,认知表现,功能和自杀倾向之间的关联.
- 在临床青年队伍中评估精神病理学,物质使用和医疗服务使用情况.
主要方法:
- 纵向队列研究设计,评估1500名年龄在11-24岁的年轻人提交到三级护理.
- 在5年内,每6个月进行一次全面的基线和后续评估.
- 心理病理学的详细表型,物质使用,功能和自杀倾向.
主要成果:
- 417名参与者被录取,平均每人3.5个精神病诊断,主要是焦虑和抑郁障碍.
- 49%的参与者达到PSS值,表现出更大的功能障碍和自杀倾向.
- PSS与增加的内化和外化症状有关.
结论:
- TAY队列研究表明,在寻求帮助的年轻人中成功进行了广泛的临床表型化.
- 在这个临床队列中,PSS的患病率明显高于社区样本.
- 早期发现强调了对临床年轻人群中精神病风险,功能和自杀倾向的纵向研究的重要性.
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