小鼠的OA易受性部分由肠道微生物组介导,可通过微生物组移植转移,并与免疫表型变化有关

Emmaline Prinz1,2, Leoni Schlupp1, Gabby Dyson1

  • 1Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

PubMed
概括

在MRL小鼠中的肠道微生物组可以预防骨关节炎 (OA). 转移这种微生物组可以降低骨关节炎的严重程度,并改变免疫细胞的特征,证明其具有保护作用.

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