在儿童结核病治疗后的肺功能结果:系统性审查和元分析
Yao Long Lew1, Angelica Fiona Tan2, Stephanie T Yerkovich3,4
1Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia yaolong.lew@menzies.edu.au.
Archives of disease in childhood
|November 18, 2023
概括
儿童结核病 (TB) 即使在治疗后,也会显著损害肺功能. 肺功能测试对于评估儿童结核病后康复的长期肺部健康至关重要.
科学领域:
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 是可以治愈的,但结核病后的肺部疾病导致全球显著的发病率.
- 目前的指导方针忽视了为肺结核 (PTB) 治疗的儿童的长期结果.
- 本综述综合了PTB治疗后儿童肺功能方面的证据.
研究的目的:
- 系统地审查和综合关于肺结核 (PTB) 治疗后儿童肺功能结果的证据.
主要方法:
- 搜索了PubMed,科学网,科克兰图书馆和ProQuest数据库,以获得仅英语研究.
- 包括观察性研究 (队列,横截面),对患者 ≤18岁,患有肺结核,接受治疗后的肺功能测试 (PFT).
- 坚持柯克伦协作和PRISMA指导方针.
主要成果:
- 五项涉及567名儿童的研究符合纳入标准.
- 从四项研究中对螺旋计数据的元分析显示,肺功能显著减少.
- 估计的效果大小表明强制呼吸量在第一个秒钟减少 (z = -1.53) 和强制生命能力 (z = -1.93) 儿童后PTB.
结论:
- 儿童PTB对肺功能有持久的负面影响.
- 肺功能测试,如螺旋计,应经常考虑在结核病治疗完成后评估儿童的长期肺部健康.
相关概念视频
Pulmonary Tuberculosis V
181
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
181
Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
Pulmonary Tuberculosis III
336
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
336
Pulmonary Tuberculosis I
245
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
245
Pulmonary Tuberculosis II
242
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
242
Pulmonary Function Tests
341
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
341


