德国瘤诱导骨质疏松症的流行病学基于真实世界的数据
Melanie May1, Ralf Oheim2, Leonore Bovy3
1Department of Payer Value & Patient Access, Kyowa Kirin GmbH, Monschauer Str. 1, 40549, Duesseldorf, Germany. Melanie.May@kyowakirin.com.
Calcified tissue international
|November 18, 2023
概括
瘤诱导性骨质疏松症 (TIO) 是一种罕见的骨疾病,在德国每10万人中发生0.187例. 这项研究提供了德国第一个关于TIO发病率和流行率的流行病学数据.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 瘤诱导骨质疏松症 (TIO) 是一种极为罕见的疾病,通常是由瘤分泌纤维细胞生长因子-23引起的.
- 非特异性症状导致诊断延迟,并对TIO患者进行具有挑战性的治疗.
- 由于TIO的稀有性,流行病学数据很少.
研究的目的:
- 量化德国TIO的发病率和流行率.
- 为德国人口中TIO提供第一个流行病学见解.
主要方法:
- 德国法定医疗保险 (SHI) 索赔数据的匿名后期分析 (大约. 5百万个体). 这是一个很好的例子.
- 由于没有唯一的TIO ICD代码,使用替代品 (ICD代码,成像,药物,瘤切除) 定义的操作类别.
- 对可能的TIO病例的计算流行率和发病率.
主要成果:
- 德国的TIO患病率确定为每10万人中0.187人.
- 发现TIO的发病率低于或等于每10万人/年0.094.
- 这项研究提供了德国TIO患者的初步流行病学数据.
结论:
- 这项分析提供了德国TIO的第一个流行病学数据.
- 尽管使用SHI对超罕见疾病的索赔数据存在局限性,但这些发现为未来的研究提供了坚实的基础.
- 需要进一步的研究来调查TIO患者的护理状况.
更多相关视频
06:00Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
7.2K
06:53Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
2.8K
相关概念视频
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K