微生物组与创伤性压力暴露后不良创伤后神经精神病学后果的发展之间的关联
Abigail L Zeamer1, Marie-Claire Salive2, Xinming An3
1Department of Microbiology and Physiologic Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Translational psychiatry
|November 18, 2023
概括
创伤幸存者发展不良的创伤后神经精神病学后果 (APNS) 显示改变了肠道微生物组. 影响L-氨酸代谢的特定微生物途径与更糟糕的APNS结果有关,这表明肠-大脑轴机制.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 在遭受创伤后,不良的创伤后神经精神病学后果 (APNS) 是常见的.
- APNS背后的生物机制在很大程度上是未知的.
- 微生物群-肠-大脑轴是理解和干预APNS的潜在途径.
研究的目的:
- 为了研究患有APNS的创伤暴露患者的肠道微生物组概况.
- 确定将肠道微生物群与APNS结果联系起来的潜在机制.
- 探索特定微生物物种,代谢途径和APNS之间的关联.
主要方法:
- 从51名遭受创伤的成年人的便样本进行了基因组学分析.
- 在2,8和12周收集创伤后结果,包括PTSD,抑郁症和体征症状.
- 应用通用线性模型和机器学习 (随机森林) 来分析微生物数据和临床结果.
主要成果:
- 一些开始性肠道微生物 (例如,Flavonifractor plautii,Ruminococcus gnavus,Bifidobacterium物种) 在患有APNS的个体中得到了丰富.
- 减少L-氨酸相关通路基因和增加氨酸和氨酸通路与更糟糕的APNS结果有关.
- 这些微生物代谢变化表明全球阿尔金因生物可用性降低,这一发现也在PTSD患者中观察到.
结论:
- 肠道微生物组失调与创伤后APNS的发展有关.
- 微生物L-氨酸代谢的改变代表了一个潜在的生物学机制,有助于APNS.
- 针对微生物群-肠-大脑轴,特别是氨酸的生物可用性,可能为APNS提供新的治疗策略.
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