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德国发病性脊髓炎的流行病学趋势:EANS脊柱截面研究
Andreas Kramer1,2,3, Santhosh G Thavarajasingam4,5,6,7, Jonathan Neuhoff8,7
1Department of Neurosurgery, University Medical Center Mainz, Mainz, Germany. andreas.kramer@unimedizin-mainz.de.
Scientific reports
|November 19, 2023
概括
发病率和死亡率在德国显著增加,特别是在老年人中. 治疗趋势显示脊柱稳定手术的增加,突显了对比治疗研究的需要.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 发烧性脊髓瘤炎带来了诊断和治疗方面的挑战.
- 了解其流行病学和德国的结果对于优化治疗至关重要.
- 关于德国当前趋势和管理的数据有限.
研究的目的:
- 描述德国发热性脊髓炎的流行病学趋势的演变.
- 评估住院患者管理策略和结果.
- 为了识别人口变化和治疗范式的变化.
主要方法:
- 基于人口的回顾性研究,使用德国联邦统计局的数据 (2005-2021年).
- 对发病趋势,人口统计,管理策略和住院患者死亡率的分析.
- 根据人口和年龄组调整的发病率的计算.
主要成果:
- 脊髓炎发病率上升了104% (每10万人中5.4至11.0),在2019年确诊的病例数量最高.
- 在老年人群 (90+,80-89,70-79) 中观察到显著增加.
- 住院患者死亡率升了347%,特别是在90岁以上组 (2450%的增加).
- 平均住院时间减少了15%,而手术干预 (脊柱稳定) 显著增加.
- 年龄和诊断年龄都显著影响了发病率.
结论:
- 德国的发病率和死亡率明显上升,不成比例地影响着老龄化人口.
- 在治疗范例中观察到向外科手术干预的转变.
- 迫切需要高水平的证据来比较手术与保守治疗,以优化治疗策略.
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