作为一个智能药物输送系统的双重pH和温度响应的聚二甲基酸 (poly ((dimethylaminoethyl methacrylate) 涂层的半孔性二氧化纳米颗粒
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Sina Ramezanian1,2, Jafarsadegh Moghaddas3,4, Hossein Roghani-Mamaqani5,6
1Chemical Engineering Faculty, Sahand University of Technology, P.O. Box 51335-1996, Tabriz, Iran.
Scientific reports
|November 19, 2023
概括
这项研究开发了对pH值和温度敏感的纳米颗粒,用于控制药物输送. 高分子量聚二甲基烯酸在酸性pH值下有效释放药物,最大限度地降低毒性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 聚合物化学 聚合物化学
背景情况:
- 开发响应刺激的药物输送系统对于向治疗至关重要.
- 纳米颗粒为药物封装和受控释放提供了一个多功能平台.
研究的目的:
- 为了制造pH和温度敏感的纳米颗粒,涂上聚二甲基甲酸 (PDMAEMA).
- 评估这些纳米颗粒对抗癌症药物的控制释放 (多克索鲁比,甲铁酸盐).
- 评估癌细胞中的体外毒性和药物释放特征.
主要方法:
- 通过在位原子转移激素聚合,将PDMAEMA移植到纳米颗粒上.
- 使用电场发射扫描电子显微镜,吸附/脱附,里埃变换红外光谱学,热重力测量分析和传输电子显微镜进行表征.
- 在不同的pH值和温度下进行体外药物释放研究,并使用HeLa细胞进行细胞毒性测定.
主要成果:
- 合成了17nm半孔纳米颗粒与移植的PDMAEMA外,具有pH (5) 和温度 (41°C) 灵敏度.
- 高分子量PDMAEMA贝证明了模型抗癌药物的受控释放,防止在中性pH和健康细胞条件下释放.
- 试验室研究表明,在酸性环境中,空白纳米颗粒的毒性最小,药物释放显著.
结论:
- 开发的PDMAEMA移植的纳米颗粒代表了一个强大的,对刺激有反应的药物输送系统.
- 该系统具有针对性癌症治疗的潜力,由于药物释放受到控制,系统毒性降低.
- 根据PDMAEMA外的可调节特性,可以根据环境触发器精确控制药物释放动力学.
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