在GC患者中,口腔微生物群疾病是由2b-RAD-M揭示的
Shengfu He1, Yating Sun1, Weijie Sun1
1Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Journal of translational medicine
|November 19, 2023
概括
口腔真菌,特别是 Malassezia globosa,显示出作为胃癌 (GC) 检测生物标志物的潜力. 这项研究确定了GC患者的真菌失衡,强调了M. globosa丰富作为诊断指标.
科学领域:
- 微生物组研究的研究.
- 胃癌 (GC) 的发病因子
- 口腔真菌生态学 口腔真菌生态学
背景情况:
- 胃癌 (GC) 与微生物群的改变有关.
- 口腔微生物群,特别是真菌在GC中的特定作用仍然在很大程度上是未知的.
- 了解口腔真菌对GC的贡献对于早期检测和治疗至关重要.
研究的目的:
- 用2b-RAD对微生物组 (2b-RAD-M) 的测序来描述胃癌 (GC) 患者的口腔微生物群.
- 调查口腔真菌和GC之间的关系.
- 为了确定潜在的口腔真菌生物标志物用于GC检测.
主要方法:
- 2b-RAD-M分析是在从GC患者和健康对照的唾液和舌头涂层样本上进行的.
- 分析了细菌和真菌的多样性,相对丰度和组成.
- 用指标分析,吉尼指数和平均下降精度来识别与GC相关的口腔真菌生物标志物.
主要成果:
- 在GC患者的口腔样本中观察到真菌失衡.
- 在GC患者中观察到马拉塞西亚全球菌 (M. globosa) 的丰富和Saccharomyces cerevisiae (S. cerevisiae) 的减少.
- 唾液和舌头涂层中的M. globosa表现出高精度 (AUC 0.976和0.846) 作为GC检测的生物标志物.
结论:
- 这项研究是第一个利用2b-RAD-M来识别口服M. globosa作为一种用于GC检测的真菌生物标志物.
- 口腔真菌的变化有助于理解GC的发展.
- 口服的M. globosa对非侵入性GC诊断具有前景.
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