在患有婴儿胆固醇病的患者中,肠道微生物群和代谢物概况的改变
Meng Jin1, Jinghua Cui2, Huijuan Ning1
1Gastroenterology Department, Children's Hospital Capital Institute of Pediatrics, Beijing, 100020, China.
BMC microbiology
|November 19, 2023
概括
婴儿胆固醇病 (IC) 与肠道微生物群的变化有关,其中Veillonella和Streptococcus菌的数量较高. 这种失生症会影响新陈代谢,可能会恶化肝损伤.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 婴儿胆固醇症 (IC) 是一种常见的婴儿肝胆道疾病,其特征是直接胆红素水平升高.
- 肝肠道循环在胆酸和胆代谢中起着至关重要的作用.
- 改变肠道微生物群的组成及其相关的代谢概况与IC的病原发生有关.
研究的目的:
- 为了研究患有IC的婴儿的肠道微生物群组成.
- 确定与IC中的微生物变化相关的异常代谢物概况.
- 探索肠道微生物群,代谢物和IC中的临床指数之间的关系.
主要方法:
- 在IC婴儿和健康对照之间对肠道微生物群组成的比较分析.
- 代谢学分析,以识别IC.中的改变代谢物.
- 微生物丰富度,代谢物和临床参数 (血清胆酸,APTT,PT,INR) 之间的相关性分析.
主要成果:
- 在IC婴儿中,Veillonella,Streptococcus和Clostridium spp.的丰富性增加. 与控制器相比,它们是.
- 在IC婴儿中观察到,Ruminococcus,Eubacterium coprostanoligenes组,肠杆菌和菌的丰度减少.
- 在IC婴儿中发现了高水平的特定脂肪酸和降低的氨基酸,与特定的微生物属和临床标记有相关性.
结论:
- 在患有IC的婴儿中存在肠道微生物群失调,有助于代谢异常.
- 这种失生症会损害肠道营养吸收,并加剧肝细胞损伤.
- 在IC中,Veillonella,Ruminococcus和Butyrivibrio被确定为潜在的重要微生物,需要进一步调查.
关键词:
但是,它们是的vibrio.我们的肠道微生物群.婴儿胆固醇症 (IC) 是一种疾病.微生物生物衍生的代谢物.鲁米诺科克斯 (Ruminococcus) 是一种菌.维龙内拉 (Veillonella) 是一种的植物.更多相关视频
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