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在没有痴呆症的老年人中,嗅觉功能障碍和认知障碍之间的关联:台湾的一项前性队列研究
Mu-Cyun Wang1,2, Jeng-Min Chiou3,4, Yen-Ching Chen5,6
1Department of Geriatrics and Gerontology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu City, Taiwan.
Journal of Alzheimer's disease : JAD
|November 19, 2023
概括
嗅觉受损与老年人认知功能较差有关. 建议对经历嗅觉衰退的老年人进行早期认知评估.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 之前关于嗅觉和认知的研究主要使用横截面设计.
- 有限的研究集中在亚洲老年人群中,研究了嗅觉功能和认知能力下降.
研究的目的:
- 研究嗅觉功能与全球/特定领域认知表现之间的关联.
- 为了检查台湾社区居住的老年人的两年内认知变化.
主要方法:
- 一项为期两年的队列研究 (2015-2019年) 涉及376名参与者,平均年龄为75.6岁.
- 使用跨文化修改的嗅探棒识别测试 (SSIT) 评估的嗅觉功能.
- 用台湾蒙特利尔认知评估 (MoCA-T) 和神经心理测试评估认知功能,使用通用线性混合模型进行分析.
主要成果:
- 降低SSIT分数 (恶化嗅觉) 与较差的全球认知,记忆和口语流性相关.
- 严重的嗅觉障碍 (厌氧症,SSIT < 8) 与正常症 (SSIT ≥ 11) 相比,与明显更差的全球认知,记忆,执行功能,注意力和口语流性有关.
- 这些关联在75岁以上的老年人,男性和非阿波利波蛋白E ɛ4载体的分层分析中仍然存在.
结论:
- 嗅觉识别的缺陷与老年人的全球和特定领域认知功能下降有关.
- 建议对有嗅觉识别障碍的老年人进行认知查,以检测潜在的认知衰退.
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