在帕金森病的OFF发作中,阿波摩尔子语言膜与皮下阿波摩尔相比:一项开放标签,随机,交叉研究
Fabrizio Stocchi1, Olivier Rascol2, Werner Poewe3
1University San Raffaele Roma and Institute for Research and Medical Care IRCCS San Raffaele Pisana, Rome, Italy.
Journal of Parkinson's disease
|November 19, 2023
概括
在帕金森病中,阿波莫芬舌下膜 (SL-APO) 的疗效与皮下阿波莫芬 (SC-APO) 的疗效相当. 由于其方便和满意度,患者对SL-APO表达了强烈的偏好.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网亚博体育官网
- 没有先前的研究前性地比较了这两种阿波莫尔芬配方的疗效和安全性.
研究的目的:
- 为了前性地比较SL-APO与SC-APO在患有帕金森病OFF发作的患者中的疗效和安全性.
主要方法:
- 一项开放标签,随机,交叉研究涉及113名患有PD和OFF发作的患者.
- 对SL-APO和SC-APO进行了剂量优化,SL-APO在诊所开始,然后在家进行进一步的优化,而SC-APO的剂量完全是在诊所内进行的.
- 患者接受了SL-APO或SC-APO的优化剂量4周,随后是洗期和4周的交叉治疗.
主要成果:
- 在第4周,SL-APO和SC-APO之间没有观察到主要终点的显著差异,即运动障碍学会统一帕金森病评分表第三部分得分的变化.
- 显著的大多数患者 (72.2%) 喜欢SL-APO而不是SC-APO.
- 患者报告说,与SC-APO相比,SL-APO对便利性和整体全球满意度的满意度更高.
结论:
- 在治疗帕金森病的过程中,SL-APO的疗效与SC-APO的疗效相当.
- 患者显然更喜欢SL-APO,报告更大的方便和满意度.
- 无论是SL-APO还是SC-APO,它们的安全性都是相似的,并且耐受性很好.
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