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建筑设计的顺序释放水凝.

Dan Zhang1, Zimu Li2, Li Yang1

  • 1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.

Biomaterials
|November 19, 2023
PubMed
概括
此摘要是机器生成的。

序列药物递送水凝 (SDDHs) 为多阶段药物释放提供了一个有前途的解决方案,模仿身体的自然过程. 本综述探讨了使用建筑原理来推进分子制药的SDDH设计.

关键词:
建筑设计是指建筑设计的设计.疾病治疗 疾病治疗水凝是一种水凝.机制 机制 机制药物递送的顺序是药物递送的顺序

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科学领域:

  • 分子制药学分子制药学
  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统

背景情况:

  • 药物协同作用已经推进了临床应用,但单次管理,多阶段释放仍然是一个挑战.
  • 由于其生物相容性和可修改性,水凝是多功能药物递送系统.
  • 顺序药物输送水凝 (SDDHs) 将水凝的好处与顺序释放能力相结合.

研究的目的:

  • 提供关于SDDHs最近发展的见解.
  • 将SDDH的构造因素 (机制,载体结构,刺激反应) 与建筑设计原则联系起来.
  • 阐明双药配合,水凝制备技术和当前的挑战.

主要方法:

  • 对用于SDDH建设的建筑设计原则的审查.
  • 在SDDH中分析机制,载体空间结构和刺激反应.
  • 讨论双药配合和先进的水凝制备技术.

主要成果:

  • 在SDDH设计元素和建筑概念 (材料,结构,交互式家具) 之间建立了平行.
  • 突出了SDDHs模拟自然生理过程以控制药物释放的潜力.
  • 确定了影响SDDH性能和未来研究方向的关键因素.

结论:

  • SDDHs代表了在实现"单次管理,多阶段释放"方面取得的重大进展.
  • 建筑设计为优化SDDH开发提供了一个有价值的框架.
  • 对双重药物策略和制备技术的进一步研究对于临床翻译至关重要.