相关实验视频

Updated: Aug 17, 2026

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

建筑设计的顺序释放水凝

Dan Zhang¹, Zimu Li², Li Yang¹

¹School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China.

|November 19, 2023

概括

序列药物递送水凝 (SDDHs) 为多阶段药物释放提供了一个有前途的解决方案,模仿身体的自然过程. 本综述探讨了使用建筑原理来推进分子制药的SDDH设计.

科学领域:

分子制药学分子制药学
生物材料科学生物材料科学
药物输送系统药物输送系统

背景情况:

药物协同作用已经推进了临床应用,但单次管理,多阶段释放仍然是一个挑战.
由于其生物相容性和可修改性,水凝是多功能药物递送系统.
顺序药物输送水凝 (SDDHs) 将水凝的好处与顺序释放能力相结合.

研究的目的:

提供关于SDDHs最近发展的见解.
将SDDH的构造因素 (机制,载体结构,刺激反应) 与建筑设计原则联系起来.
阐明双药配合,水凝制备技术和当前的挑战.

主要方法:

对用于SDDH建设的建筑设计原则的审查.
在SDDH中分析机制,载体空间结构和刺激反应.
讨论双药配合和先进的水凝制备技术.

主要成果:

在SDDH设计元素和建筑概念 (材料,结构,交互式家具) 之间建立了平行.
突出了SDDHs模拟自然生理过程以控制药物释放的潜力.
确定了影响SDDH性能和未来研究方向的关键因素.

结论:

SDDHs代表了在实现"单次管理,多阶段释放"方面取得的重大进展.
建筑设计为优化SDDH开发提供了一个有价值的框架.
对双重药物策略和制备技术的进一步研究对于临床翻译至关重要.

关键词:

建筑设计是指建筑设计的设计.疾病治疗疾病治疗水凝是一种水凝.机制机制机制药物递送的顺序是药物递送的顺序

更多相关视频

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...