阻塞性睡眠呼吸暂停在快速眼动睡眠和成年人的认知表现
Xiao Tan1, Mirjam Ljunggren1, Lena Kilander2
1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Sleep medicine
|November 19, 2023
概括
在REM睡眠期间阻塞性睡眠呼吸暂停 (OSA) 可能会影响老年人的注意力. 具体来说,较高的REM睡眠呼吸暂停事件与60岁及以上的人在认知测试中的表现较慢有关.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与认知能力下降有关.
- 快速眼动 (REM) 睡眠期间的OSA可能会出现更严重的呼吸事件和氧气不和.
- 雷姆睡眠OSA在认知障碍中的特定作用仍未得到充分研究.
研究的目的:
- 调查OSA之间的关联,特别是在REM睡眠期间,和认知功能.
- 为了确定REM睡眠期间的OSA是否是认知衰退的重要因素.
主要方法:
- 一项对728名成年人 (平均年龄59.1岁) 的横截面研究,使用多睡眠学来评估呼吸暂停-呼吸暂停指数 (AHI) 和睡眠阶段.
- 使用Trail Making Test (TMT) A和B部分评估认知功能.
- 线性回归分析对全样本和60岁以上具有足够REM睡眠的参与者的亚样本进行了分析.
主要成果:
- 在完整的样本中,在整体OSA (AHI ≥5) 和TMT-B表现之间发现了轻微的关联,但与TMT-A无关.
- 在老年参与者 (≥60岁) 中,较高的REM特异性AHI (≥5事件/小时) 与TMT-A的表现较慢显著相关.
- 在老年人中,REM特异性AHI和TMT-B表现之间没有发现任何关联.
结论:
- 在REM睡眠期间的OSA可能会在老年人中不成比例地影响与注意力相关的认知功能.
- 针对OSA患者的REM睡眠障碍可能对保持老年人的认知健康至关重要.
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