胃食道逆流性疾病和鼻炎:双向的门德尔随机化研究
Teng-Yu Chen1, Ming-Hui Lv2, Ren-Jie Lai2
1Department of Otolaryngology, Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China, chenty57@mail2.sysu.edu.cn.
International archives of allergy and immunology
|November 19, 2023
概括
胃食道逆流性疾病 (GERD) 增加慢性鼻炎 (CRS) 的风险,可能是急性鼻炎 (ARS) 的风险因素. 这项研究调查了GERD和RS之间的因果关系,提供了对疾病机制的见解.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学是一种遗传学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 胃食道逆流性疾病 (GERD) 是患有鼻炎 (RS) 的患者常见的并发症.
- GERD和RS之间的确切因果关系仍然不完全理解.
- 这项研究旨在阐明GERD与急性 (ARS) 或慢性RS (CRS) 之间的潜在因果关系.
研究的目的:
- 使用孟德尔随机化研究GERD和ARS/CRS之间的因果关系.
- 为RS的发病和管理提供证据.
- 探索RS的潜在风险因素.
主要方法:
- 利用来自综合流行病学单位Open GWAS项目和FinnGen (N=972,838) 的大规模遗传数据.
- 作为主要分析,采用逆方差加权 (IVW) 方法.
- 采用了敏感性分析,包括加权中位数,MR-Egger,MR-PRESSO和留出一项分析,以确保结果的稳定性.
主要成果:
- 发现GERD和CRS风险增加之间存在显著的关联 (OR:1.36,p < 0.001).
- 确定了与ARS风险增加相关的GERD (OR: 1.31,p < 0.001).
- 没有发现显著的异质性,性或从RS到GERD的反向因果关系的证据.
结论:
- GERD是一个潜在的因果风险因素,促进了CRS的发展.
- GERD也可能导致ARS的风险.
- 这些发现需要进一步调查连接GERD和RS的潜在机制.
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