巴托内拉汉塞拉作为慢性2型麻风反应的可疑触发因素
Luciene Silva Dos Santos1, Marina Rovani Drummond1, Isabela Maria Bernardes Goulart2
1Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Laboratório de Pesquisa Aplicada em Dermatologia e Infecção por Bartonella, Campinas, SP, Brazil.
概括
慢性2型麻风反应可能是由巴托内拉汉塞莱感染引发的. 与对照组相比,患有这些反应的患者患有巴托内拉亨塞莱感染的患病率更高.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 麻风反应是导致身体残疾的重要原因之一.
- 麻风反应的免疫抑制治疗增加了对共感染的易感性.
- 同感染可以加速新的或持久的麻风反应.
研究的目的:
- 调查巴托内拉菌种类的流行情况. 在患有慢性2型麻风反应的患者中感染.
- 为了比较Bartonella sp. 患者和对照组之间的感染率.
- 评估 Bartonella henselae 在引发慢性2型麻风反应中的潜在作用.
主要方法:
- 从47名患有慢性2型麻风反应的患者和50名对照患者收集了血液样本.
- 使用培养物和分子方法,包括PCR,检测巴托内拉sp.
- 使用特定物种的PCR和测序来识别和确认.
主要成果:
- 在患有慢性2型麻风反应的患者中,Bartonella henselae感染在40.4% (19/47) 发现.
- 在对照组中,巴托内拉汉塞拉菌感染的流行率为18.0% (9/50).
- 五名为Bartonella henselae共感染而接受治疗的患者显示,他们的麻风反应有所改善.
结论:
- 巴托内拉汉塞拉感染在患有慢性2型麻风反应的患者中更为普遍.
- 巴托尼拉汉塞拉可能会起到2型慢性麻风病反应的触发作用.
- 对巴托内拉菌的调查sp. 建议在患有持续的2型麻风反应的患者中进行感染.
相关概念视频
Hypersensitivities
684
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
684
Allergic Reactions
27.5K
Overview
27.5K
Pulmonary Tuberculosis III
336
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
336
Pulmonary Tuberculosis II
242
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
242
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Allergic Drug Reactions
849
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
849


