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细胞和生物材料传递策略,以诱导免疫耐受性

Brianna L Scotland¹, Jacob R Shaw², Shruti Dharmaraj¹

¹Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201, United States.

Advanced drug delivery reviews

|November 19, 2023

概括

向疗法旨在恢复对自身免疫性疾病和过敏的免疫耐受性. 通过利用自然途径和创新的交付,这些策略承诺更安全,更有效的治疗,没有广泛的免疫抑制.

科学领域:

免疫学免疫学免疫学
免疫治疗是一种免疫疗法.
耐受性诱导是一种诱导.

背景情况:

免疫媒介疾病的患病率上升,如自身免疫性疾病和过敏.
当前非特异性疗法的局限性导致普遍免疫抑制.
需要有针对性的方法来解决潜在的致病机制.

研究的目的:

审查中央和外围免疫耐受性的自然机制.
探索针对抗原特异性免疫耐受性的创新传递策略.
讨论对耐药性策略的临床实施的挑战和机会.

主要方法:

描述身体的自然免疫耐受机制.
使用细胞和生物材料的新型传递系统的概述.
对向天生的和适应性免疫细胞的策略的分析.

主要成果:

鉴定抗原特异性方法来抑制异常免疫激活.
利用内在耐受性途径,以获得有针对性的治疗益处.
有可能避免与普遍免疫抑制相关的不良影响.

结论:

抗原特异性免疫耐受性对治疗免疫媒介疾病具有显著的前景.
创新的交付策略对于有效的临床翻译至关重要.
需要进一步的研究,以克服实施宽容疗法的挑战.

关键词:

适应性免疫反应适应性免疫反应收养细胞疗法收养细胞疗法抗原输送系统的抗原输送系统自身免疫性疾病是一种自身免疫性疾病.免疫耐受性是一种免疫耐受性.天生的免疫反应.纳米颗粒纳米颗粒

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