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来自Alstonia scholaris的未描述的内醇乳可以保护肝细胞受损

Bin-Yuan Hu¹, Yun-Li Zhao¹, Ying-Jie He¹

¹Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650501, PR China.

|November 19, 2023

概括

来自Alstonia scholaris的六种新型的类化物,alstolactines F-K,表现出强大的抗炎作用. 这些化合物降低关键的炎症蛋白质的调节,提供潜在的治疗益处.

科学领域:

自然产品化学自然产品化学
药用化学医学化学
药理学药理学是指药理学的学科.

背景情况:

阿尔斯托尼亚学士是一种生物活性化合物的植物来源.
印度醇化物代表着具有各种生物活动的多样化的自然产品类别.

研究的目的:

从Alstonia scholaris中分离和表征新型的醇化物.
为了评估分离的化合物的抗炎潜力.

主要方法:

使用色谱技术分离和净化类化合物.
通过广泛的光谱分析 (NMR,MS) 和X射线衍射来阐明结构.
量子化学计算用于结构确认.
使用LPS诱导的人体正常肝细胞 (LO2) 细胞进行体外测试以评估抗炎活性.

主要成果:

鉴定出了6种新的印类化物,即阿尔斯托拉丁F-K (1-6).
化合物1和2具有罕见的6/5/6/6/7环系统,并呈现出一种新的C5→C20-olide结构.
综合体3展示了独特的降解C18和C19结构.
1-6化合物显著降低了LPS诱导的LO2细胞中包括NLRP3,TLR4,NF-κB和p38在内的炎症蛋白的表达.

结论:

这项研究成功地从Alstonia scholaris中分离和表征了新型的醇化物.
已识别的化合物,阿尔斯托拉丁F-K,显示出显著的抗炎生物活性.
这些发现表明这些类化合物的潜在治疗应用在管理炎症状况.

关键词:

阿尔斯托尼亚学子 (L.) R. Br. Br.抗炎生物活性抗炎生物活性在 Apocynaceae 中.印度醇类化合物印度醇类化合物

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