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动物和植物之间的替代拼接的差异及其潜在的潜在因素
Yunfei Du1, Lu Cao1, Shuo Wang1
1State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Lin'an, 311300, Hangzhou, China.
Journal of advanced research
|November 19, 2023
概括
替代拼接 (AS) 在真核生物中创建多样化的转录. 本综述探讨AS机制和动物和植物之间的差异,影响疾病和作物发展.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 植物科学 植物科学
- 动物科学动物科学
背景情况:
- 替代拼接 (AS) 是一个关键的转录后过程,在真核生物中产生转录多样性.
- AS失调与动物的癌症和植物的压力反应等疾病有关.
- 虽然在动物和植物中已知AS的作用,但对机制和差异的比较评论很少.
研究的目的:
- 在真核生物的生物过程中提供对替代拼接 (AS) 的全面理解.
- 阐明导致动物和植物之间AS差异的分子机制和因素.
- 为了比较AS调节,包括无意义介导的mRNA衰变 (NMD),并讨论未来的影响.
主要方法:
- 在动物和植物中对替代拼接 (AS) 机制进行比较分析.
- 评估影响AS的因素,包括基因组架构,拼接因素和环境刺激.
- 在两个王国中检查无意义介导的mRNA衰变 (NMD) 途径.
主要成果:
- AS对动物和植物的遗传和表型多样性做出了重大贡献.
- 在AS过程中的差异受到外子/内子结构,UTRs,结合体组件,染色体动态,转录速度,拼接因子 (SR蛋白,hNRNP),非编码RNA和环境线索的影响.
- 无意中介的mRNA衰变 (NMD) 途径在处理过早终结子 (PTC) 时表现出动物和植物之间的差异.
结论:
- 了解动物和植物之间的AS差异对于推进生物知识至关重要.
- 对AS的比较见解可以为开发新型疾病疗法和改进作物品种提供信息.
- 对AS机制的进一步研究将释放出在医学和农业中的潜在应用.
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