功能快速下降增加了一般人群中骨折风险:来自TLGS的见解
Soroush Masrouri1, Farzad Esmaeili1, Maryam Tohidi1
1Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bone
|November 19, 2023
概括
快速功能衰退 (RKFD) 在一般人群中显著增加骨折风险. 早期识别和治疗RKFD对于预防骨折至关重要,即使在没有慢性病的个体中也是如此.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 之前的研究将慢性病 (CKD) 与骨折联系起来,但估计膜过率 (eGFR) 降低的影响不太清楚.
- 这项研究独特地调查了伊朗普通人口中功能快速下降 (RKFD) 和骨折发生率之间的关联.
研究的目的:
- 检查RKFD与一般人口队列中的各种骨折结果之间的关联.
- 确定性别或现有的CKD状态是否会改变RKFD对骨折风险的影响.
主要方法:
- 一项德黑兰社区的队列研究将RKFD定义为在2-3年内30%的eGFR下降.
- 考克斯的比例危险模型被采用,调整了许多人口,临床和生活方式因素.
- 分析了骨折结果,包括任何骨折,下肢和主要骨质疏松性骨折.
主要成果:
- 在5305名患者的9.62年的随访中,RKFD与任何骨折的风险增加2.18倍有关.
- 在下肢骨折 (HR 2.32) 和严重骨质疏松性骨折 (HR 2.91) 中发现了显著的关联.
- 这些风险在考虑到相应的死亡风险后仍然显著,并没有因性别或CKD状态而显著改变.
结论:
- 在一般人群中,RKFD是骨折发病率增加的独立风险因素.
- RKFD和骨折之间的关联甚至在没有先前存在的CKD的个体中也是显著的.
- 强调需要早期检测和管理策略,以帮助那些经历快速EGFR衰退的个体.
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