在认知健康的老年人中,白质超强度,缺口,内腔皮层厚度,宣言性记忆和休活动之间的关联:一项为期7年的研究
Isabel Hotz1, Pascal Frédéric Deschwanden1, Susan Mérillat1
1Dynamics of Healthy Aging, University Research Priority Program (URPP), University of Zurich, Stampfenbachstrasse 73, Zurich CH-8006, Switzerland.
NeuroImage
|November 19, 2023
概括
活跃的生活方式和更厚的内耳皮层 (EC) 可能会防止老化中的记忆力下降. 休活动和认知储备可能会抵消神经退行,但需要对大脑健康的可修改因素进行更多研究.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 大脑小血管疾病 (cSVD) 是老年人群认知能力下降的重要因素.
- 了解cSVD,大脑缩 (特别是脑内皮层厚度) 和记忆之间的相互作用对于健康的衰老至关重要.
- 生活方式因素在cSVD和认知健康中的神经保护作用仍未得到充分研究.
研究的目的:
- 在健康的老年人中,研究cSVD标记物 (白质高强度,缺口),内腔皮层厚度和宣言记忆之间的纵向关联.
- 检查休活动 (身体,社会,认知),cSVD,皮层厚度和宣言记忆之间的关系.
- 确定影响cSVD进展和认知衰退的混因素.
主要方法:
- 长度研究利用结构性MRI和231名健康老年人 (年龄在64-87岁) 的认知/调查数据,持续了7年.
- 隐性增长曲线建模用于分析轨迹和跨域相关性,控制混因素.
- 计算了休活动得分,并评估了与大脑结构和记忆的关联.
主要成果:
- 基线较厚的内耳皮层 (EC) 预测了较少的宣言性记忆丧失,较少的与年龄相关的EC稀释与保存的记忆有关.
- 较高的体力和社交休活动与右 EC 的较小稀释有关.
- 白质过强度 (WMH) 或缺陷与声明性记忆之间,或休活动与记忆之间没有发现直接联系.
- 高等教育最初与更好的记忆力和体力活动相关,但呈现出更的下降.
- 肥胖与较低的身体/社会活动和较薄的左侧EC有关. 抗高血压药物,酒精使用和吸烟影响了缺口的进展.
结论:
- 在cSVD标记物,内皮层厚度,宣言性记忆和生活方式因素之间存在复杂的相互关系.
- 休活动和认知储备似乎在抵消与cSVD相关的神经退行起作用.
- 诸如生活方式,肥胖和药物使用等可修改因素显著影响cSVD进展和认知健康,需要进一步调查干预措施.
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