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Updated: Jul 10, 2025

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针对GRN mRNA中miR-29b结合部位的反感性寡核酸增加了progranulin的翻译

Geetika Aggarwal1, Subhashis Banerjee1, Spencer A Jones1

  • 1Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri, USA; Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St Louis, Missouri, USA; Institute for Translational Neuroscience, Saint Louis University, St Louis, Missouri, USA.

The Journal of biological chemistry
|November 19, 2023
PubMed
概括

反感性寡核酸 (ASO) 可以通过阻断microRNA结合部位来增加progranulin蛋白水平. 这种新的方法显示了对前性痴呆症 (FTD) 和其它哈普隆缺陷障碍的治疗潜力.

关键词:
反感的寡核化物.前性痴呆症前性痴呆症简单的说来,是没有足够的.这是一个微型RNA.益格拉努林是一种前列腺素.

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