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Updated: Jul 10, 2025

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抗体药物合物超出了细胞毒性有效载荷的范围

Adrian D Hobson1

  • 1Small Molecule Therapeutics & Platform Technologies, AbbVie Bioresearch Center, Worcester, MA, United States.

Progress in medicinal chemistry
|November 19, 2023
PubMed
概括

抗体药物合物 (ADC) 现在提供针对性交付的多种有效载荷超出细胞毒剂的癌症治疗. 新的非细胞毒性有效载荷,包括葡萄糖皮质体受体调节器 (GRMs),扩大了ADC在瘤学和其他领域的治疗潜力.

关键词:
抗体药物联合体 (ADC) 是一种抗体药物联合体.可切割的链接器葡萄糖皮质体受体调节器 (GRM)希斯脱乙酶 (HDAC) 的使用免疫学ADC (iADC) 是一种免疫学ADC.免疫刺激性ADC (isADC) 是一种素螺旋蛋白 (KSP) 是一种蛋白质.尼古丁胺胺酸基转移酶 (NAMPT) 的使用不能切割的链接器这是一种类固醇.干扰素基因 (STING) 的刺激器收费类受体 (TLR) 是一种类型的受体.

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