动脉样硬化心血管疾病风险和乳腺癌患者的纵向风险因素管理
John W Melson1, Benjamin Koethe2, Sharanya Mohanty3
1Division of Hematology Oncology, Tufts Medical Center, Boston, MA.
Clinical breast cancer
|November 19, 2023
概括
乳腺癌幸存者面临着动脉样硬化心血管疾病 (ASCVD) 的高风险. 许多患有高ASCVD风险或现有疾病的幸存者没有接受指南推的预防药物.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病是乳腺癌幸存者的首要死亡原因.
- 有限的数据存在于动脉样硬化心血管疾病 (ASCVD) 的风险和预防性药物使用在这个人群.
- 这项研究解决了乳腺癌幸存者的患者水平ASCVD风险评估和管理的需要.
研究的目的:
- 在非转移性乳腺癌患者中描述ASCVD风险.
- 在这个队列中评估ASCVD预防药物的纵向使用.
- 在乳腺癌幸存者中发现ASCVD风险管理方面的差距.
主要方法:
- 对326名非转移性乳腺癌患者进行了回顾性队列研究.
- 收集有关人口统计,临床特征,实验室研究和药物暴露的数据.
- 使用非实验室临床参数计算出10年估计的ASCVD风险.
主要成果:
- 在诊断时,7.1%的人已经确立了ASCVD. 除其他外,25.4%的10年ASCVD风险≥20%,37.6%的风险为7.5%至<20%.
- 66.3%的人有降脂治疗的适用性;57.0%的人接受了类药.
- 随访时血压>140/90 mmHg是常见的 (33.0%-55.6%).
结论:
- 该队列中的大多数乳腺癌患者在诊断时患有ASCVD风险较高.
- 可修改的ASCVD风险因素通常未经治疗或未经控制的癌症后治疗.
- 需要改善乳腺癌幸存者的ASCVD风险管理.
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