基于身体构成和预后营养指数的诺莫图谱预测了胃癌治愈切除术后的生存率
Chao Tao1, Wei Hong1, Pengzhan Yin1
1Department of Radiology, the First Affiliated Hospital of Wannan Medical College, Wuhu, China (T.C., W.H., P.Y., S.W., Z.L., Y.Y.).
Academic radiology
|November 19, 2023
概括
定量计算断层扫描 (QCT) 和预后营养指数 (PNI) 确定了手术后胃癌 (GC) 患者的生存因素. 一个名图模型预测了接受治愈切除术的GC患者的个性化预后.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 营养 营养 营养 营养 营养
背景情况:
- 胃癌 (GC) 仍然是一个重大的全球健康挑战.
- 准确的预后对于治疗切除后有效的患者管理至关重要.
研究的目的:
- 为了确定胃癌 (GC) 患者治疗后切除后的独立预后因素.
- 开发一个使用定量计算断层扫描 (QCT) 和预后营养指数 (PNI) 进行个性化预后的诺莫格拉姆预测模型.
主要方法:
- 对经过治愈切除的119名GC患者的回顾性分析.
- 量化计算机断层扫描 (QCT) 参数 (BMD,SMA,VFA,SFA,CTFF) 和它们的变化 (Δ) 被评估.
- 多变量考克斯回归建立了一个基于独立预后因子 (ΔCTFF, ΔVFA, ΔBMD, PNI) 的名录.
主要成果:
- ΔCTFF, ΔVFA, ΔBMD 和 PNI 被确定为整体存活时间 (OS) 的独立预后因素.
- 诺米图表表现出强大的预测性能,在1,3年和5年 (0.816,0.815,0.881) 的ROC曲线下的高面积.
- 该模型达到0.743的C指数,并显示出良好的临床净益.
结论:
- 一个整合身体组成 (通过QCT) 和PNI的诺莫格拉姆模型可靠地预测GC患者在治疗切除后的个性化存活率.
- 这个工具有助于个性化预后评估胃癌管理.
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