进激素异常:与进激素失衡相关的多种疾病领域
Guiwu Huang1, Jinlong Jian2, Chuan-Ju Liu3
1Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA; Department of Orthopaedic Surgery, New York University Grossman School of Medicine, New York, NY, USA; Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China.
Cytokine & growth factor reviews
|November 19, 2023
概括
进蛋白素 (PGRN) 对 lysosomal 功能至关重要,并影响许多疾病,统称为进蛋白素病变. 本综述探讨了PGRN在健康和疾病中的双重作用,强调了其治疗潜力.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
背景情况:
- 由GRN基因编码的progranulin (PGRN) 是一种被分泌的生长因子,参与瘤发生,炎症和神经增殖.
- GRN突变与神经退行性和溶酶体储存疾病有关,确定了PGRN作为溶酶体蛋白质的关键作用.
- PGRN不平衡导致各种疾病,包括自身免疫,代谢,肌肉骨和心血管疾病,称为progranulinopathy.
研究的目的:
- 提供关于Progranulin (PGRN) 在Progranulinopathy病变发生过程中的新兴作用的最新审查.
- 阐明PGRN与细胞外和细胞内各类蛋白质之间的复杂分子相互作用.
- 探索导致Progranulinopathy的病理生理机制,并确定潜在的研究途径.
主要方法:
- 关于Progranulin (PGRN) 和Progranulinopathy的现有研究的综合文献综述.
- 分析PGRN作为细胞外生长因子和细胞内共同参与者的双重功能.
- 在各种疾病背景下检查涉及PGRN的分子相互作用和信号通路.
主要成果:
- 进蛋白素 (PGRN) 既作为细胞外信号分子,又作为细胞内辅助分子,对蛋白质折叠和贩运至关重要,特别是溶解体水解酶.
- 在中枢神经系统和外围系统中,PGRN的陪伴活动对其多样化的功能至关重要.
- PGRN不平衡是广泛疾病的基础 (Progranulinopathy),影响多个器官系统.
结论:
- 进激素 (PGRN) 在维持细胞平衡和预防各种疾病方面发挥着多方面的作用.
- 了解PGRN复杂的蛋白相互作用和伴侣功能是解开Progranulinopathy机制的关键.
- 对PGRN复杂作用的进一步研究可能会揭示对Progranulinopathy的新型治疗策略.
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