含有释放的颗粒的玻璃离子体水泥:对牙矿物质含量和机械性能的影响
Handially S Vilela1, Mariana C A Resende1, Rafael B Trinca1
1Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
概括
将酸 (HAp) 或酸 (CaSi) 添加到玻璃离子体水泥 (GIC) 中,增加了离子释放和受影响的压力强度 (CS). 然而,与对照组相比,这两种修改都没有促进牙重矿化.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料工程 生物材料工程
- 矿化组织工程 矿化组织工程
背景情况:
- 玻璃离子体水泥 (GIC) 在修复性牙科中被广泛使用.
- 用酸 (HAp) 和酸 (CaSi) 等生物活性颗粒来增强GIC,以改善其性能.
- 了解这些修改对离子释放,机械性质和牙重矿化的影响,对于临床应用至关重要.
研究的目的:
- 为了研究将酸 (HAp) 或酸 (CaSi) 颗粒纳入玻璃离子体水泥 (GIC) 对非矿物化牙的影响.
- 评估这些修改对离子释放,压力强度 (CS),矿物质含量和牙机械性能的影响.
- 评估修改的GICs在非矿物化牙上的重矿化潜力.
主要方法:
- 玻璃离子体水泥 (GICs) 被修改为5%的HAp或5%的CaSi按质量.
- 使用ICP-OES和离子特定电极量化离子释放 (Ca2+,Sr2+,F-).
- 无矿化牙在模拟体液 (SBF) 中暴露在水泥中八周,通过ATR-FTIR评估重矿化 (矿物质:矩阵比率,MMR).
- 使用纳米沉积方法测量了牙硬度 (H) 和弹性模量 (E).
- 水泥的压力强度 (CS) 在24小时7天后进行了测试.
主要成果:
- 与对照组相比,经过修改的GIC表现出明显更高的Ca2+和Sr2+释放量.
- GIC与HAp显示F-释放增加,而CaSi没有显著改变F-释放.
- 所有组都显示MMR增加,在8周后他们之间没有显著差异.
- 两组之间没有观察到牙硬度或弹性模块的显著差异.
- 用HAp修改的GIC显示出更高的初始CS,而CaSi添加则降低了CS. 7天后,GIC+CaSi的CS值低于对照组和GIC+HAp.
结论:
- 用HAp或CaSi修改GIC可以增强离子释放,并影响压力.
- 尽管离子释放增加,但与对照组相比,HAp和CaSi的修饰都没有导致牙重矿化.
- 需要进一步的研究来优化GIC配方,以提高重矿化功效.
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