素饮食通过影响肠道微生物群来改善神经系统疾病吗? 一个系统的审查
Mahdi Mazandarani1,2, Narges Lashkarbolouk1,2, Hanieh-Sadat Ejtahed3
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Nutrition journal
|November 20, 2023
概括
性饮食 (KD) 显著改变神经病患者的肠道微生物群 (GM),影响疾病的严重程度和复发. 这些饮食变化影响细菌组成和代谢物水平,提供了潜在的治疗机制.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 饮食科学 饮食科学
背景情况:
- 肠道微生物群 (GM) 在神经健康中起着至关重要的作用.
- 性饮食 (KD) 在神经疾病中的治疗潜力越来越多地被探索.
- 了解KD诱导的转基因变异可能会揭示神经改善的机制.
研究的目的:
- 系统地审查由性饮食 (KD) 诱导的肠道微生物群 (GM) 的变化.
- 评估这些转基因变化的潜在作用,作为改善神经疾病的机制.
主要方法:
- 在PubMed/Medline,科学网和Scopus的综合文献搜索,直到2022年12月.
- 包括临床试验和队列研究,详细介绍KD神经病患者的转基因变化.
- 使用纽卡斯尔-太华尺度和Cochrane协作工具进行质量评估;由两名研究人员独立提取数据.
主要成果:
- 13项研究表明,通过减少疾病的严重程度和复发,KD可以改善神经系统的结果.
- KD改变了转基因成分,增加了蛋白质细菌和特定属 (例如,Bacteroides),同时减少了Firmicutes和Actinobacteria.
- KD修改了代谢物概况,减少了短链脂肪酸,增加了β-基酸和三甲基胺N-氧化物.
结论:
- 性饮食 (KD) 显然改变了神经病患者的肠道微生物群 (GM) 组成.
- 基因转基因及其代谢物的KD诱导的变化代表了神经疾病改善的潜在机制.
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