可打印的微封装甲酸用于个性化的局部配送
Lapporn Vayachuta1, Meyphong Leang1, Jareerat Ruamcharoen2
1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Khlong Luang, Pathum Thani 12120, Thailand.
ACS applied bio materials
|November 20, 2023
概括
研究人员开发了可打印的微封装甲酸 (AA),用于使用激光打印进行个性化的局部输送. 这种方法为有针对性的护肤应用提供了一种新的方法,其细胞毒性最小.
科学领域:
- 材料科学与工程 材料科学与工程
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 亚酸 (AA) 是一种重要的抗氧化剂,局部稳定性和皮肤透性有限.
- 需要个性化的局部递送系统来增强像AA这样的活性成分的疗效.
- 激光打印技术为精确和可定制的化品和治疗剂的配方提供了潜力.
研究的目的:
- 开发可打印的微缩甲酸 (AA) 用于个性化的局部输送.
- 用米粉和纳米来优化AA的封装和打印过程.
- 使用乳液载体系统评估封装AA的局部输送和皮肤透.
主要方法:
- 在米粉中微封装AA (10%的AA含量),用疏水性纳米处理.
- 使用商用激光打印机制造微封装AA图案.
- 用乙烯糖醇 (P5G) 或二乙烯糖醇单乙烯 (DEGEE) 制备乳液载体系统.
- 使用具有Strat-M膜的弗朗茨扩散细胞评估局部吸收.
- 对纤维细胞细胞的细胞毒性评估.
主要成果:
- 成功制造可打印的微封装AA,印刷有轻微的缺陷.
- 实现了0.28 mg/cm2的AA封装.
- 经证实增强的皮肤透度,稳定状态流量为8.40微克/小时/厘米2 (P5G) 和10.04微克/小时/厘米2 (DEGEE).
- 确认封装产品和载体系统的低细胞毒性.
结论:
- 可打印的微封装AA可以使用激光打印技术成功制造.
- 开发的乳液载体系统有效地增强了AA透到皮肤.
- 这项技术有望为个性化局部输送带有良好的安全性配置的 Askorbic 酸提供希望.
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