接种SARS-CoV-2疫苗后的基库奇病:一个病例报告与免疫组织化学分析
Yuichiro Hamamoto1,2, Michihiro Kawamura3, Hideo Mori4
1Department of Diagnostic Pathology, Kinki Central Hospital, Itami, Hyogo, Japan.
International journal of surgical pathology
|November 20, 2023
概括
在接种了SARS-CoV-2疫苗后的患者中观察到一种罕见的基库奇病,即淋巴结疾病. 这项研究是第一个在接种疫苗后在基库奇病淋巴结中检测SARS-CoV-2表达的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 由于COVID-19大流行,导致SARS-CoV-2疫苗接种的广泛普及.
- 淋巴腺病是已知的SARS-CoV-2疫苗的潜在副作用之一.
- 基库奇病 (胞性死性淋巴腺炎) 是一种罕见的良性疾病,影响淋巴结.
研究的目的:
- 报告在SARS-CoV-2疫苗接种后发生的罕见基库奇病例.
- 在受影响的淋巴结中调查SARS-CoV-2的存在.
主要方法:
- 宫淋巴腺病的临床表现和成像 (CT扫描).
- 诊断程序包括精细针吸收和淋巴结的手术切除.
- 针对SARS-CoV-2检测的细胞病理学检查和免疫组织化学检查.
主要成果:
- 一名41岁的男性在mRNA-1273疫苗接种9天后出现了宫淋巴腺病和发烧.
- 组织病理学证实了基库奇病的特征性淋巴结变化.
- 免疫组织化学揭示了受影响淋巴结中的小淋巴细胞内的SARS-CoV-2阳性细胞.
结论:
- 这是 SARS-CoV-2 疫苗接种后首次报告的基库奇病例.
- 这项研究表明,SARS-CoV-2在基库奇病变中的表达,这表明存在潜在的联系.
- 需要进一步的研究,以了解这种罕见的疫苗相关不良事件的免疫病原发生.
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