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在情绪障碍和自杀行为的人群中,前扣状皮层的休息状态功能连接

Elisa Ambrosi¹, Kaylah N Curtis¹, Puneetha Goli¹

¹Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (all authors); Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, Houston (Curtis, Salas); Department of Neuroscience, Rice University, Houston (Goli); Department of Research, Menninger Clinic, Houston (Patriquin, Salas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Fondazione Policlinico Universitario Agostino Gemelli, Scientific Institute for Research, Hospitalization and Healthcare, Rome (Simonetti); Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Scientific Institute for Research, Hospitalization and Healthcare, Rome (Spalletta).

The Journal of neuropsychiatry and clinical neurosciences

|November 20, 2023

概括

前带带皮质 (ACC) 中的静止状态功能连接 (rsFC) 发生变化与严重抑郁和双相情感障碍中自杀行为史有关. 这些ACC异常可能在自杀风险的神经生物学中发挥作用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经成像是一种神经成像.

背景情况:

重度抑郁症 (MDD) 和双相情感障碍 (BD) 与增加自杀风险有关.
前带带皮层 (ACC) 功能障碍与情绪障碍和自杀行为有关.
了解自杀行为的神经相关性对于开发有针对性的干预措施至关重要.

研究的目的:

调查前带带皮层 (ACC) 分区的静止状态功能连接 (rsFC) 异常是否与患有MDD或BD的患者的自杀行为 (SB) 史有关.
为了比较具有或没有自杀行为史和健康对照个体之间的ACC rsFC模式.

主要方法:

休息状态功能连接 (rsFC) 神经成像对42名住院患者进行了自杀行为史 (SB+),26名住院患者没有自杀行为史 (SB-),以及40名健康对照 (HC).
用种子对声和兴趣区域 (ROI) 对ROI分析计算了亚阴茎,阴茎,面上,背部和尾部ACC分区的rsFC.
分析对潜在的混因素如精神病和抑郁症严重程度进行了控制.

主要成果:

与SB和HC组相比,SB+组在左侧正面和右侧背部ACC种子和视觉皮层集群之间表现出更高的rsFC.
相反,在SB+组与HC组相比,左侧正面和右侧背部ACC种子和带带肌/正面集群之间的rsFC在SB+组较低.
左面角ACC与左边布罗德曼区域18之间的连接在区分SB+和SB-患者中表现出高达75%的准确性.

结论:

患有MDD或BD的自杀行为史与面额和尾部ACC的改变rsFC有关.
这些ACC区域参与冲突检测和错误监测,这表明它们在自杀行为的神经生物学中的作用.
需要进一步的研究和复制来确认ACC参与自杀行为和想法.

关键词:

前肢皮层前肢皮层前肢皮层双极性障碍是一种双极性障碍.功能连接的功能连接.严重的抑郁症严重的抑郁症自杀的想法和行为.自杀自杀的自杀是自杀的自杀.

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