从现实环境移植的腹困难,特别关注困难杆菌感染
Uday Yanamandra1, Alka Khadwal2, Setu Gupta3
1Professor, Department of Medicine & Hematology, Armed Forces Medical College, Pune, India.
Medical journal, Armed Forces India
|November 20, 2023
概括
血造干细胞移植 (HSCT) 后腹很常见,影响超过84%的患者. 然而,Clostridium difficile感染并不常见,这表明非传染性原因通常是导致HSCT后腹的原因.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 腹是血液造血干细胞移植 (HSCT) 患者的不适和疾病的重要来源.
- 腹的原因可以是传染性或非传染性.
研究的目的:
- 在现实环境中确定HSCT患者腹的发病率和特征.
- 为了比较自身和异性HSCT之间的腹发病率.
- 评估HSCT后腹患者中Clostridium difficile的发生率和抗菌剂的使用情况.
主要方法:
- 一个前性的,单中心的观测研究在北印度进行.
- 在约4年的时间里,观察了105名接受HSCT的患者 (72名自主,33名全源).
- 收集的数据包括腹发病率,持续时间,C. difficile检测和抗生素使用.
主要成果:
- 腹发生在84.7%的患者中,平均持续时间为8.39天.
- 在异构和自身移植之间没有观察到腹发病率的显著差异.
- 困难菌仅在7.6%的腹患者中检测到; 甲尼达是主要使用的抗生素.
结论:
- 腹是HSCT后的常见并发症.
- 困难性闭杆菌不是这种患者群体中腹的常见原因.
- 对于腹,应考虑非传染性病因,特别是在异构移植接受者中.
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