相关实验视频

Updated: Jul 10, 2025

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

将抗氧化剂富勒纳纳入酸骨增强细胞骨质生成,而不会影响物理水泥特性

İlayda Duru¹, Nisa Irem Büyük², Gamze Torun Köse²

¹Institute of Biomedical Engineering Boğaziçi University Rasathane Street, Üsküdar, İstanbul 34684, Turkey.

Advanced engineering materials

|November 20, 2023

概括

富勒通过改善酸水泥来增强骨再生. 这种抗氧化剂增强了骨质分化和细胞活力,显示了骨重建的前景.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

酸水泥 (CPC) 对于骨重建至关重要.
提高CPC的骨质生成潜力仍然是一个关键的挑战.
富勒 (Ful),是一种C60富勒衍生物,表现出抗氧化特性.

研究的目的:

调查富勒醇被纳入碳甲基纤维素/凝改性CPC (CMC/Gel) 的情况.
评估富勒对CPC机械性能,抗氧化活性和骨质生成能力的影响.
评估富勒醇作为骨组织工程中的亲骨质原剂添加剂的潜力.

主要方法:

在CPC中添加了生物相容的富勒素颗粒,其度各不相同 (0.02,0.04,0.1重量v%^-1).
评估了机械性能,设置时间和抗氧化活性 (ROS清理).
在体外细胞毒性和细胞骨质生成 (ALP活性,Runx2表达) 用MC3T3-E1细胞进行了评估.

主要成果:

最高的富勒醇度降低了由于增强的结合而导致的水泥固时间.
富勒的加入显著提高了ROS清除能力,最佳活性在0.02和0.04重量v%^-1.
富勒的低度 (0.02和0.04重量v%^-1) 保护了细胞活力,促进了骨质分化.

结论:

富勒在CPC中充当强大的抗氧化剂和亲骨质原剂.
富勒醇载CPC的骨质生成潜力与它们的抗氧化活性直接相关.
富勒作为先进骨重建材料的添加剂显示出显著的前景.

关键词:

富勒诺是一种富勒诺.抗氧化剂抗氧化剂是一种抗氧化剂.骨头骨头骨头骨头酸水泥是一种酸水泥.骨质原性差异化骨质原性差异化

更多相关视频

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

相关概念视频

Hydration of Cement

Hydration of Cement

Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...

Porosity in Cement Paste

Porosity in Cement Paste

The porosity of concrete is a measure of the void spaces within its structure. These spaces impact its strength and durability significantly. When water and cement interact, a chemical reaction called hydration creates a semi-solid paste. This paste includes combined water, making up approximately 23% of the cement's dry mass, and gel water, which fills minuscule voids known as gel pores, accounting for about 28% of the cement gel volume.
The balance of water to cement in the mix is...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Additives and Fillers in Concrete

Additives and Fillers in Concrete

Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...