帕金森病震对莱沃多巴和下丘脑刺激的反应不同
Thomas Wirth1,2,3,4, Francisca Ferreira1,5, Nirosen Vijiaratnam1
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Movement disorders clinical practice
|November 20, 2023
概括
帕金森病的震反应因乐伏多巴和STN-DBS而异. 姿势震的严重程度预测反应不佳,而休息震和更高的休息/姿势比率表明帕金森病患者的结果更好.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 运动障碍 运动障碍
背景情况:
- 帕金森病 (PD) 震对莱沃多巴和脑下深层刺激 (STN-DBS) 的反应不一致.
- 识别震反应的预测因素对于优化治疗策略至关重要.
研究的目的:
- 确定预测帕金森病患者对levodopa和STN-DBS震反应的因素.
- 为了将震子组件的严重程度与治疗结果相关联.
主要方法:
- 在165名PD患者中使用统一帕金森病评分表-III项目评估了Levodopa和STN-DBS震反应.
- 利用休息/姿势震比率和多重线性回归来确定预测因素.
- 对激活组织体积进行了基于voxel的分析,以绘制症状改善区域.
主要成果:
- 男性性别与勒沃多巴震反应负相关.
- 较高的休息/姿势震比率与勒沃多巴和STN-DBS震反应正相关.
- 震改善集群位于体内核,不确定的区域和体内核.
结论:
- 更严重的姿势震和不太严重的休息震与较差的利沃多巴和STN-DBS反应有关.
- 独特的解剖网络可能是STN-DBS对震的影响与其他帕金森症症状的基础.
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