相关实验视频

Updated: Jul 10, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

微RNAs:关键目标治疗类风湿性关节炎的血管生成

Lingyun Zhao¹, Qingze Wu¹, Yiying Long²

¹College of Acupuncture, Tuina and Rehabilitation, Hunan University of Chinese Medicine, Changsha, China.

Journal of drug targeting

|November 20, 2023

概括

微RNAs (miRNAs) 是类风湿性关节炎 (RA) 炎症和血管新生代的关键调节剂. 需要进一步的研究来了解miRNA在血管发育中的作用,以改善RA治疗策略.

科学领域:

* 分子生物学 * 分子生物学
* 免疫学免疫学
* 风湿病学风湿病学

背景情况:

* 血管新生是类风湿性关节炎 (RA) 炎症的一个关键事件,驱动突血管网络的形成和疾病的持续性.
*微RNAs (miRNAs) 是调节基因表达的小型非编码RNAs,并与涉及血管新生病有关.
*目前对miRNA参与RA相关的血管新生代的理解有限,需要进一步调查.

研究的目的:

*为了突出miRNAs在风湿性关节炎的背景下在血管新生中的关键作用.
*强调需要实验验证miRNA-疾病关联及其在血管发育途径中的特定功能.
* 倡导进一步研究miRNA-目标基因相互作用,以开发针对RA的新型治疗策略.

主要方法:

*对miRNAs,血管新生和类风湿性关节炎的现有文献的综述.
*讨论miRNAs在基因表达中的调节机制.
* 建议未来的实验方法,包括蛋白质组学和转录组学.

主要成果:

*miRNAs在与血管新生代相关的条件下被差异地表达.
*miRNAs在与疾病相关的血管新生代中发挥着重要作用.
*需要进行进一步的研究,以阐明血管发育和RA中的特定miRNA功能.

结论:

*阐明miRNA及其基因在血管发育中的精确作用对于推进RA治疗至关重要.
*先进的生物技术方法,如蛋白质组学和转录组学,可以更深入地了解miRNA的表达和调节.
*对miRNA的全面研究为治疗RA和类似疾病中的血管新生提供了战略基础.

关键词:

类风湿性关节炎类风湿性关节炎类风湿性关节炎血管新生是因为血管新生.基于miR的治疗方法微RNAs 是一个微型RNA.治疗目标是治疗的目标.

更多相关视频

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...