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计算机模拟将机械振动应用于介质细胞干细胞,用于对骨组织工程进行机械调制

Mohammadreza Mohseni¹, Bahman Vahidi¹, Hamidreza Azizi¹

¹Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

|November 20, 2023

概括

机械振动和流体流动在体外显著调节介质干细胞 (MSCs). 这项研究使用了数值建模来揭示这些刺激如何影响MSC,确定机械传导的最佳条件.

科学领域:

生物物理学的生物物理.
细胞力学细胞力学
生物技术是生物技术.

背景情况:

了解细胞对机械刺激的反应对于在体外调节细胞行为至关重要.
机械振动和振荡流体流动是干细胞机械调节的关键生物物理信号.

研究的目的:

通过数值建模,研究振动和振荡流体对介质干细胞 (MSC) 和它们的组件的联合作用.
为了在体外确定MSC的最佳机械刺激条件.

主要方法:

利用有限元法 (FEM) 和流体结构相互作用 (FSI) 模型进行数值模拟.
分析了MSC的机械反应 (压力和应变),包括细胞质,细胞核,活性蛋白和微管.
作为机械受体,被认为是整合素和初级纤毛.

主要成果:

在机械振动的特定频率下观察到最高的细胞反应 (压力和应变).
由于流体流动,细胞在[特定范围]范围内经历剪切应力.
细胞表面的机械受体受到水力动力压力的高度刺激,在MSC机械调制中发挥作用.

结论:

该研究提供了关于MSC在联合振动和流体流动下机械调节的见解.
结果可以优化细胞培养中的机械刺激条件,用于未来的研究.
这些发现有助于理解干细胞中机械转导的机制.

关键词:

细胞力学细胞力学细胞骨架细胞骨架流体结构相互作用.机械调制是机械调制的方法.机械振动是一种机械振动.振荡式流体流的流量流动.

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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...