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Updated: Jun 15, 2026

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
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作为潜在的VEGFR抑制剂的新型N-arylmethyl-aniline/chalcone混合物:合成,生物评估和分子动力学模拟

Hesham Haffez1,2, Nosaiba A Elsayed3, Marwa F Ahmed3

  • 1Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Ain Helwan, Egypt.

Journal of enzyme inhibition and medicinal chemistry
|November 20, 2023
PubMed
概括

新型混合分子被合成并测试了抗癌性质及其抑制VEGFR-2的能力,这是瘤生长的关键因素. 化合物5e和5h显示出显著的潜力,诱导癌细胞的亡和细胞循环停止.

关键词:
在VEGFR-2的基础上,抗癌剂是一种抗癌剂.诱导性亡诱导性亡分子对接的分子对接.

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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