胎儿MRI基础的身体和肥胖的量化为小的妊娠年龄周产期风险分层分层
Aviad Rabinowich1,2,3, Netanell Avisdris1,4, Bossmat Yehuda1,5
1Sagol Brain Institute, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Journal of magnetic resonance imaging : JMRI
|November 20, 2023
概括
妊娠年龄较小的胎儿的胎儿体积和脂肪与身体比率的减少与对非安抚胎儿状况和新生儿不良事件进行干预的风险增加有关.
科学领域:
- 医疗成像医学成像
- 胎儿医学 胎儿医学
- 新生儿结局的结果.
背景情况:
- 对于妊娠年龄 (SGA) 较小的胎儿面临不良围产期结果的风险增加.
- 胎儿的身体组成提供了对营养状况和潜在的预后价值的见解.
- 对胎儿人类学的MRI量化可以改善SGA风险分层.
研究的目的:
- 调查由MRI获得的胎儿身体组成指标与SGA胎儿的不良周产期结果之间的关联.
- 为了确定MRI衍生胎儿人类学是否可以预测需要产科干预或新生儿不良事件.
主要方法:
- 涉及40名SGA胎儿的前性研究,通过MRI评估 (3-T,TruFISP,T1W迪克森序列).
- 深度学习用于胎儿身体和皮下脂肪的自动细分,以计算总体体积 (TBV),脂肪信号分数 (FSF) 和脂肪与身体体积比 (FBVR).
- 单变量和多变量逻辑回归分析了TBV,FBVR,FSF和非安抚胎儿状态 (NRFS) 或新生儿不良事件 (CANO) 的产科干预之间的关联.
主要成果:
- 减少的FBVR (OR 0.39) 和FSF (OR 0.95) 与NRFS干预相关.
- 较低的TBV (OR 0.69) 和FSF (OR 0.96) 与CANO.相关.
- 对于产科干预,FBVR显示出高灵敏度 (85.7%) 和特异性 (87.5%);对于CANO,TBV显示出82.35%的灵敏度和86.4%的特异性.
结论:
- 在SGA胎儿中,总体体积 (TBV) 和脂肪与体积比率 (FBVR) 的降低与产科干预和新生儿不良结果的增加率相关.
- 基于MRI的胎儿身体组成分析显示,SGA怀孕中风险分层增强具有前途.
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