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прополис涂层对子宫内器械抗菌耐药性的影响
Alparslan Deniz1, Tunca Karasu2, Neslihan İdil3
1Department of Obstetrics and Gynecology, Alanya Alaaddin Keykubat University, Alanya, Turkiye.
Journal of biomaterials science. Polymer edition
|November 20, 2023
概括
粉涂层通过改善抗菌性质和减少生物膜形成,显著增强了子宫内置器械 (IUD). 这种天然剂为预防IUD相关感染提供了一个有希望的替代品.
科学领域:
- 生物材料科学 生物材料科学
- 预防传染病 预防传染病
- 自然产品化学 自然产品化学
背景情况:
- 宫内器械 (IUD) 是有效的避孕药,但由于长时间的植入,容易受到细菌污染和生物膜的形成.
- 避孕套中的金属成分提供了一些抗菌功效,但感染仍然是一个问题.
- 是一种天然树脂产品,具有已知的抗菌和抗病毒特性.
研究的目的:
- 评估作为天然涂层剂,以增强宫内节育器的抗菌特性.
- 调查不同粉涂层策略对常见细菌菌株的疗效.
- 评估 прополис对防止IUD表面生物膜形成的影响.
主要方法:
- 测试了三种粉涂层方法:直接涂在金属上,涂在聚合物上,并使用载体聚合物.
- 使用动态细菌培养测试对*黄金葡萄球菌* (格拉姆阳性) 和*大肠杆菌* (格拉姆阴性) 进行抗菌活性评估.
- 生物膜形成阻力通过特定的生物膜抑制测试来评估.
主要成果:
- прополис涂层表现出高抗菌抑制,达到高达99.5%的*大肠杆菌*和98.5%的*金黄色.
- 携带聚合物方法提高了表面均性和抗菌效果.
- 生物膜形成的抗性显著增强,大肠杆菌的改善率为44.33%,大黄金菌的改善率为45.99%.
结论:
- 是一种高效的天然剂,可提高宫内节育器的抗菌性能.
- 粉涂层,特别是使用载体聚合物,显著减少了细菌污染和生物膜的形成.
- 是一种有前途的替代涂层材料,用于开发具有增强安全性质的下一代宫内节育器.
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