基于正念的减轻压力减少了亲炎性基因调节,但不是老年人系统性炎症:一项随机对照试验
Emily K Lindsay1, Anna L Marsland, Steven W Cole
1From the Department of Psychology (Lindsay, Marsland, Wright), University of Pittsburgh, Pittsburgh, Pennsylvania; Departments of Medicine and Psychiatry & Biobehavioral Sciences (Cole), UCLA School of Medicine, Los Angeles, California; Department of Psychology (Dutcher, Brown, Creswell), Carnegie Mellon University; and University of Pittsburgh School of Medicine (Greco), Pittsburgh, Pennsylvania.
正念训练减少了老年人的细胞炎症标志物,但没有影响循环中的蛋白质. 这表明正念对衰老和健康的特定细胞益处.
科学领域:
- 老年学是指老年学的学科.
- 心理神经免疫学 心理神经免疫学
- 分子生物学分子生物学
背景情况:
- 衰老会增加炎症和易受压力的可能性,影响健康.
- 正念干预可以减轻压力和炎症.
- 以前的研究表明,正念会影响炎症路径.
研究的目的:
- 为了调查正念训练是否会降低孤独的老年人中的促炎基因表达和全身炎症标志物.
- 检查基于正念的压力减轻 (MBSR) 对特定转录因子和炎症蛋白的影响.
主要方法:
- 190名孤独的老年人 (65-85岁) 被随机分配到为期8周的MBSR或健康增强计划 (HEP).
- 通过RNA分析,评估了外围血液单核细胞中的转录因子活性 (NF-κB,CREB,IRF,GR).
- 在干预前,干预后和3个月的随访后,测量了白血清中介质素-6 (IL-6) 和C反应蛋白 (CRP) 的水平.
主要成果:
- 与HEP相比,MBSR显著降低了核因子kB (NF-kB) 的活性 (p = .028).
- 没有观察到MBSR对CREB,IRF或GR活动的显著影响.
- 循环IL-6和CRP水平在MBSR和HEP组之间并没有随着时间的推移而有所不同.
结论:
- 在孤独的老年人中,MBSR有效地降低了细胞的炎症性基因调节,可能降低了疾病风险.
- 正念干预措施没有显著改变系统性炎症 (IL-6,CRP) 的循环蛋白标志物.
- 研究结果突出了特定的细胞机制,通过这种机制,正念可能会影响老年人群中的炎症和健康.
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