18 F-FDG PET/MRI用于经过新辅助化疗或放射治疗后食道癌的再分期
Maria J Valkema1, Quido G de Lussanet de la Sablonière2, Roelf Valkema2
1Departments of Surgery.
Nuclear medicine communications
|November 20, 2023
概括
18F-氧葡萄糖 (18F-FDG) PET/MRI显示,在治疗食道癌的新辅助化疗后,瘤检测与PET/CT相似. 进一步优化协议可能会提高其在检测残留疾病的准确性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 食道癌症的治疗通常涉及新辅助化疗或放射治疗 (nCRT).
- 准确评估治疗反应对于指导进一步管理至关重要.
- 通常使用的是18F-化氧葡萄糖 (18F-FDG) PET/CT,但在检测残留疾病方面存在局限性.
研究的目的:
- 评估18F-氧糖 (18F-FDG) PET/MRI在食道癌的nCRT后改善瘤检测的潜力.
- 为了比较18F-FDG PET/MRI与18F-FDG PET/CT的诊断准确性,用于识别残留的初级瘤和淋巴结转移.
主要方法:
- 展望性,单中心可行性研究,涉及21名患者.
- 患者接受了18F-FDG PET/CT,随后在nCRT后6-12周接受了18F-FDG PET/MRI.
- 手术样本的组织病理学作为参考标准;诊断准确性由两个独立的读者团队评估.
主要成果:
- 18F-FDG PET/MRI的诊断准确度为38-57%的yp/ycT+和53-63%的ypN+.
- 18F-FDG PET/CT的准确率为61-76%的年/年cT+和42-63%的年N+.
- 无论是SULmax还是ADC的平均值都没有歧视性地检测残留疾病.
结论:
- 目前,18F-FDG PET/MRI的性能与18F-FDG PET/CT在nCRT后的瘤检测中相当.
- 扫描协议的改进,阅读器体验的增强和串行成像可能会提高18F-FDG PET/MRI的准确性.
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