用放射性治疗格雷夫斯甲状腺功能障碍症:格雷夫斯轨道病变的发生率
Nicole Q X Quah1, Manvi M Sobti1, Alison M Wren2
1Departments of Ophthalmology.
Nuclear medicine communications
|November 20, 2023
概括
对Graves病的放射性 (RAI) 治疗导致Graves轨道病 (GO) 的发病率降低. 大多数新的GO病例发生在不接受类固醇预防的高风险患者中.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 核医学是一种核医学.
背景情况:
- 格雷夫斯病是一种影响甲状腺的自身免疫性疾病.
- 格雷夫斯轨道病 (GO) 是一种相关的自身免疫性疾病,影响眼睛.
- 放射性 (RAI) 治疗对GO发展或再激活的影响需要进一步研究.
研究的目的:
- 在RAI治疗后对格雷夫斯病患者的GO发病率进行审计.
- 识别与RAI后的GO开发或重新激活相关的风险因素.
- 评估类固醇预防的使用和有效性,以预防RAI后的GO.
主要方法:
- 在5年内对101名接受RAI治疗的格雷夫斯病患者进行了回顾性审计.
- 收集的数据包括吸烟状况,TRAb水平,GO史,眼睛特征,类固醇预防,RAI剂量和治疗后的甲状腺状况.
- 分析了GO的发生率,风险因素和结果.
主要成果:
- 在5.0%的患者中发生GO;80%的新病例发生在不接受类固醇的高风险个体中.
- 尽管使用类固醇,但发生了一例GO重新激活.
- 大多数患者在RAI后的一年内达到甲状腺功能低下的状态.
结论:
- 对格雷夫斯病的RAI治疗与较低的GO发病率有关.
- 对GO风险因素的治疗前评估和患者咨询至关重要.
- 建议在类固醇预防中采取涉及内分泌学家和眼科医生的多学科决策.
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