改变的大规模休息状态功能网络连接在收不充分的年轻人与双眼正常控制相比
Farzin Hajebrahimi1, Suril Gohel1, Mitchell Scheiman2
1Department of Health Informatics, Rutgers University School of Health Professions, Newark, New Jersey, United States.
Investigative ophthalmology & visual science
|November 20, 2023
概括
这项研究发现,与对照人群相比,成年人患有收性缺陷 (CI) 的休息状态功能连接性 (RSFC) 降低. 这些神经差异与视觉功能缺陷相关,这表明CI的神经生理基础.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 趋同缺陷 (CI) 是一种常见的视觉障碍,影响近工作.
- 神经生理学基础的CI还没有完全理解.
研究的目的:
- 研究症状性CI患者与双眼正常对照者的静止状态功能连接 (RSFC) 差异.
- 探索RSFC变化与CI的临床测量之间的关系.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估49名CI患者和47名BNC的RSFC.
- 采用了集团级独立组件分析和双回归.
- 线性回归分析了临床视觉功能测量和RSFC之间的相关性.
主要成果:
- 与BNC相比,CI患者在前面对面,默认模式和视觉网络中表现出较低的RSFC.
- 默认模式网络的RSFC强度与接近点的融合和合度量有显著的相关性.
结论:
- 改变的RSFC在CI患者中明显明显,与对照人群相比.
- 这些神经生理学差异可能与用于诊断CI的光学视觉功能有关.
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